The San Francisco 49ers will look for their first home victory in four tries when they take on the NFC West-rival Los Angeles Rams on Sunday Night Football. The 49ers, who have lost two in a row overall, are coming off a 43-17 thrashing by the Miami Dolphins last week. The Rams, meanwhile, have won two straight, including a 30-10 win at Washington. San Francisco is 0-1 in the division, while Los Angeles is playing its first divisional foe of the season.
Kickoff from Levi’s Stadium is set for 8:20 p.m. ET. The Rams are three-point favorites in the latest 49ers vs. Rams odds from William Hill, while the over-under is 51.5. Before making any Rams vs. 49ers picks, check out the NFL predictions from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It’s off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 run on top-rated NFL picks that dates back to the 2017 season.
The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on 49ers vs. Rams. You can visit SportsLine now to see the picks. Here are the NFL lines and trends for Rams vs. 49ers:
- 49ers vs. Rams spread: Rams -3
- 49ers vs. Rams over-under: 51.5 points
- 49ers vs. Rams money line: Rams -170, 49ers +150
- LAR: Seventh in rushing yards per game (142.3)
- SF: Over has hit in three Niners games this season
Why the Rams can cover
Quarterback Jared Goff is off to a fast start to the season, completing 109 of 152 passes for 1,372 yards and eight touchdowns. Last week against Washington, he passed for 309 yards and two touchdowns with one interception for a rating of 111.7. He also rushed for a score. He is looking for his third straight road game with 300 passing yards and seventh road game in a row with multiple TD passes.
Also leading the offense is running back Darrell Henderson Jr. He had 68 yards from scrimmage last Sunday, including 38 rushing, with receiving and rushing TDs. It was his first two-TD game of his career. He has four touchdowns in his past three games on the road. For the season, he has carried 58 times for 260 yards and three touchdowns.
Why the 49ers can cover
Despite that, Los Angeles is not a lock to cover the Rams vs. 49ers spread. That’s because San Francisco is still a formidable opponent despite missing several key players due to injury, including defensive ends Ezekiel Ansah (biceps) and Nick Bosa (ACL), who are out for the season.
Quarterback Jimmy Garoppolo (ankle)